A rare architectural gem by Ortiz Mexia Projects, 1378 Appleton Way masterfully blends modern design with total privacy on one of the largest residential lots in Venice. At the heart of the home is an exquisitely appointed chef's kitchen and open-concept living area that opens out to an entertainer's dream backyard complete with a heated pool, integrated spa, fire pit, built-in BBQ, and multiple zones for relaxing or hosting. The expansive native gardens, thoughtfully designed by renowned landscape architect Jeff Pervorse of Bent Grass, create a lush, botanical oasis in the heart of Venice. Upstairs features three bedrooms, two full baths, a media-viewing loft, and a sprawling outdoor deck, providing a private outdoor rooftop space for reading, relaxing and much more. The second floor showcases rich Brazilian Cumaru wood flooring, adding warmth and elegance throughout the private living quarters. Downstairs, artisan concrete tiles by Ogassian bring a modern edge to the space. The custom Hinoki Japanese soaking tub is the centerpiece of a beautifully designed full bathroom. Positioned along the side of the home, it creates a seamless transition from swim to soak, offering a truly restorative indoor-outdoor experience. Just beside it, the downstairs guest bedroom features direct access to the front yard, reinforcing the home's effortlessly relaxed, California lifestyle. A detached studio in front of the house offers flexibility as an office, gym, or overflow guest space, while the two-car garage includes a fully equipped guest house above, complete with its own kitchenette and bathroom ideal for a private workspace or long-term guests. Located just blocks from Venice favorites like Superba, Zinque, and the neighborhood's newest hotspot, Beethoven Market, this is Venice Beach living at its finest architectural, elevated, and effortlessly connected to the best of the Westside.